Using Twitter: Do You Have Tips?

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After perusing this directory of publishing industry people on Twitter,
I finally created a Twitter account for the Writer's Digest community
(@WritersDigest if you would like to follow, and @JaneFriedman if you
would like to specifically follow me).

I have been quite lax in using
Twitter; right now I prefer Facebook and blogging. If I consistently and thoroughly followed everyone
I'm interested in (probably more than several hundred people), I sense it would be like drinking from a fire hose—and would I be
able to accomplish anything if distracted every 5-10 minutes by updates?

I wonder how both unpublished and published writers are using Twitter.
Do you have a Twitter account? Are you actively using it? And if so,
has it changed anything about your writing and publishing life? What
tips do you have for other writers?