Spot on, Rob and Ostarella!
You don’t tailor a manuscript for an agent, an editor, friends, family, a critique group, beta readers, or the marketplace. You simply write the best book of which you’re capable. You write the sort of novel you yourself would love to read. In other words, you don’t write what you know (terrible advice), you write what you love.
After submitting, an agent or an editor may well suggest some changes. It’s up to you whether to make them. But that happens *after* the submission process, not before.